Bioinformatic identification of genes suppressing genome instability

Bioinformatic identification of genes suppressing genome instability.

Unbiased forward genetic screens for mutations causing increased gross chromosomal rearrangement (GCR) rates in Saccharomyces cerevisiae are hampered by the difficulty in reliably using qualitative GCR assays to detect mutants with small but significantly increased GCR rates. We therefore developed a bioinformatic procedure using genome-wide functional genomics screens to identify and prioritiz...

Genome-Wide Identification of KANADI1 Target Genes

Plant organ development and polarity establishment is mediated by the action of several transcription factors. Among these, the KANADI (KAN) subclade of the GARP protein family plays important roles in polarity-associated processes during embryo, shoot and root patterning. In this study, we have identified a set of potential direct target genes of KAN1 through a combination of chromatin immunop...

Bioinformatic approaches for genome finishing

Role of the mismatch repair gene, Msh6, in suppressing genome instability

Special RepoRt Bioinformatic identification of novel methyltransferases

Methyltransferases & epigenomics In recent years, we have witnessed greatly expanded attention to the enzymes that catalyze the transfer of methyl groups from S-adenosylmethionine (AdoMet) to DNA, RNA, proteins, lipids and small molecules [1]. The central role of methyltransferases in epigenetics was first realized with enzymes modifying DNA [2,3]; subsequent work has demonstrated the importanc...